Scientific literature about the role of collagene in the human body

    Research data show the impact on daily life. All studies are made with the specific ingredients of BELLAPUR products.   
    Skin & hair
    Cartilage
    Ligaments & tendons
    Bones
    Muscles

    Effect on skin, fingernails and hair

    • Oesser S ‘The oral intake of specific Bioactive Collagen Peptides has a positive effect on hair thickness’ Nutrafoods 2020; 1: 134-138   LINK
    • Hexsel D. et al. ‘Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails’ J Cosmet Dermatol. 2017; 16(4): 520-526   LINK
    • Knefeli HC, Durani B ‘Improved wound healing after oral application of specific bioactive collagen peptides’ Nutrafoods 2017: 9-12
    • Schunck M et al. ‘Dietary Supplementation with specific collagen peptides has a body mass index-dependent beneficial effect on cellulite morphology’ 2015; J Med Food 2015; 18 (12): 1340-1348   LINK
    • Proksch E et al. ‘Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis’ Skin Pharmacol Physiol 2014; 27: 113-119   LINK
    • Proksch E et al. ‘Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study’ Skin Pharmacol Physiol 2014; 27: 47-55   LINK

    Effect on articular cartilage and mobility

    • Zdzieblik, D. et al. ‘The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial.’ Nutrients, 2021; 13, 523   LINK
    • Zdzieblik D et al. ‘Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptide ’ Appl Phsiol Nutr Metab. 2017 Jun; 42(6): 588-595   LINK
    • Gonçalves FK. ‘Impact of collagen hydrolysate in middle-aged athletes with knee and ankle osteochondral lesions: A case series.’ Int J Case Rep Images 2017; 8(6): 364–369   LINK
    • Oesser S et al. ‘Orally administered collagen hydrolysate halts the progression of osteoarthritis in STR/ort mice’ Osteoarthritis and Cartilage 2017, Vol. 15, Supplement C61-C62, P 94   LINK
    • Oesser S et al. ‘Efficacy of specific bioactive collagen peptides in the treatment of joint pain’ Osteoarthritis and Cartilage 2016; Vol. 24, Suppl. 1: 189   LINK
    • McAlindon TE et al. ‘Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial’ Osteoarthritis and Cartilage 2011; Vol. 19 (4) : 399 – 405   LINK
    • Oesser S et al. ‘Prophylactic treatment with a special collagen hydrolysate decreases cartilage tissue degeneration in the knee joints’ Osteoarthritis Cartilage 2008; 16 (Suppl 4): p. S45   LINK
    • Clark KL et al. ‘24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain.’ Current Medical Research and Opinion 2008; Vol. 24 (5); 1485–1496   LINK
    • Oesser S, Seifert J ‘Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen ‘ Cell Tissue Res 2003; 311: 393–399   LINKP

    Effect on ligaments & tendons in daily life and sport activity

    • Jerger S et al. ‘Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties’ Scand J Med Sci Sports, 2022 Apr 11. doi: 10.1111/sms.14164. LINK 
    • Praet SFE et al. ‘Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients’ Nutrients. 2019; 11(1): 76   LINK
    • Dressler P et al. ‘Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability’ Journal of Sports Science and Medicine 2018; 17, 298-30   LINK
    • Schunck M, Oesser S ‘Specific collagen peptides benefit the biosynthesis of matrix molecules of tendons and ligaments’ J Int Soc Sports Nutr 2013, 10, P23   LINK
    •  Moskowitz R ‘Role of collagen hydrolysate in bone and joint disease’ Semin Arthritis Rheum. 2000 Oct;30(2):87-99.   LINK

    Effect on bone

    • Zdzieblik D et al. ‘Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women’ Journal of Bone Metabolism 2021;28(3):207-213. LINK
    • König D et al. ‘Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled Study ’ Nutrients 2018; 10(1): 97   LINK
    • Argyrou C et al. ‘Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia’ J Musculoskelet Neuronal Interact. 2020 Mar 3;20(1):12-17.   LINK
    • Knefeli HC, Müller-Autz M ‘Improved bone healing after oral application of specific bioactive collagen peptides’ Nutrafoods 2018; 17:185-188   LINK

    Effect on muscle development and sport activity

    • Centner C et al. ‘Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction.’ Front. Physiol. , 2022; 13:838004. doi: 10.3389/fphys.2022.838004  LINK
    • Jendricke P et al. ‘Influence of Specific Collagen Peptides and Concurrent Training on Cardiometabolic Parameters and Performance Indices in Women: A Randomized Controlled Trial.’ Front. Nutr. 2000; 7:580918   LINK
    • Oertzen-Hagemann V et al. ‘Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men’ Nutrients. 2019 May 14;11(5):1072.   LINK
    • Krimse M et al. ‘Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men’ Nutrients 2019 May 23;11(5):1154   LINK
    • Jendricke P et al. ‘Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial’ Nutrients 2019 Apr 20;11(4):892   LINK
    • Zdzieblik D et al. ‘Effect of specific collagen peptides with various dosages on body composition in untrained men’ Proceedings of the Nutrition Society , Volume 76 , Issue OCE4: Summer Meeting, 10–12 July 2017, Improving Nutrition in Metropolitan Areas , 2017 , E211   LINK
    • Zdzieblik D et al. ‘Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial‘ British Journal of Nutrition 2015 Oct; Vol. 114(8): 1237 – 1245   LINK